Implications of mitochondrial network organization in mitochondrial stress signalling in NARP cybrid and Rho0 cells.

ABSTRACT: Mitochondrial dysfunctions lead to the generation of signalling mediators that influence the fate of that organelle. Mitochondrial dynamics and their positioning within the cell are important elements of mitochondria-nucleus communication. The aim of this project was to examine whether mitochondrial shape, distribution and fusion/fission proteins are involved in the mitochondrial stress response in a cellular model subjected to specifically designed chronic mitochondrial stress: WT human osteosarcoma cells as controls, NARP cybrid cells as mild chronic stress and Rho0 as severe chronic stress. We characterized mitochondrial distribution in these cells using confocal microscopy and evaluated the level of proteins directly involved in the mitochondrial dynamics and their regulation. We found

SUBMITTER: Walczak J 

PROVIDER: S-EPMC5665886 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature