Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types.

ABSTRACT: Hepcidin is a small cysteine rich peptide that regulates the sole known cellular iron exporter, ferroportin, effectively controlling iron metabolism. Contrary to humans, where a single hepcidin exists, many fish have two functionally distinct hepcidin types, despite having a single ferroportin gene. This raises the question of whether ferroportin is similarly regulated by the iron regulator Hamp1 and the antimicrobial Hamp2. In sea bass (Dicentrarchus labrax), iron overload prompted a downregulation of ferroportin, associated with an upregulation of hamp1, whereas an opposite response was observed during anemia, with no changes in hamp2 in either situation. During infection, ferroportin expression decreased, indicating iron withholding to avoid microbial proliferation. In vivo administrati

SUBMITTER: Neves JV 

PROVIDER: S-EPMC5665920 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature