Developmental increases in white matter network controllability support a growing diversity of brain dynamics.

ABSTRACT: As the human brain develops, it increasingly supports coordinated control of neural activity. The mechanism by which white matter evolves to support this coordination is not well understood. Here we use a network representation of diffusion imaging data from 882 youth ages 8-22 to show that white matter connectivity becomes increasingly optimized for a diverse range of predicted dynamics in development. Notably, stable controllers in subcortical areas are negatively related to cognitive performance. Investigating structural mechanisms supporting these changes, we simulate network evolution with a set of growth rules. We find that all brain networks are structured in a manner highly optimized for network control, with distinct control mechanisms predicted in child vs. older youth. We demons

SUBMITTER: Tang E 

PROVIDER: S-EPMC5665937 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature