TREM-1 promotes intestinal tumorigenesis.

ABSTRACT: Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory innate immune responses. Increasing evidence suggests a role for TREM-1 not only in acute pathogen-induced reactions but also in chronic and non-infectious inflammatory disorders, including various types of cancer. Here, we demonstrate that genetic deficiency in Trem1 protects from colorectal cancer. In particular, Trem1 ^-/- mice exhibited reduced tumor numbers and load in an experimental model of inflammation-driven tumorigenesis. Gene expression analysis of Trem1 ^-/- versus Trem1 ^+/+ tumor tissue demonstrated distinct immune signatures. Whereas Trem1 ^-/- tumors showed an increased abundance of transcripts linked to adaptive immunity, Trem1 ⁺

SUBMITTER: Saurer L 

PROVIDER: S-EPMC5665947 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature