Tumor endothelial cells with high aldehyde dehydrogenase activity show drug resistance.

ABSTRACT: Tumor blood vessels play an important role in tumor progression and metastasis. We previously reported that tumor endothelial cells (TEC) exhibit several altered phenotypes compared with normal endothelial cells (NEC). For example, TEC have chromosomal abnormalities and are resistant to several anticancer drugs. Furthermore, TEC contain stem cell-like populations with high aldehyde dehydrogenase (ALDH) activity (ALDH^high TEC). ALDH^high TEC have proangiogenic properties compared with ALDH^low TEC. However, the association between ALDH^high TEC and drug resistance remains unclear. In the present study, we found that ALDH mRNA expression and activity were higher in both human and mouse TEC than in NEC. Human NEC:human microvascular endothelial cells (

SUBMITTER: Hida K 

PROVIDER: S-EPMC5666026 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature