Clinical and microbiological features of infection in alcoholic hepatitis: an international cohort study.

ABSTRACT:

Background

Previous studies have described the clinical impact of infection in alcoholic hepatitis (AH) but none have comprehensively explored the aetiopathogenesis of infection in this setting. We examined the causes, consequences and treatment of infection in a cohort of patients with AH.

Methods

We undertook a retrospective cohort study of patients with AH admitted between 2009 and 2014 to seven centres in Europe and the USA. Clinical and microbiological data were extracted from medical records. Survival was analysed with Kaplan-Meier analysis and Cox proportional hazards analysis to control the data for competing factors. Propensity score matching was used to examine the efficacy of prophylactic antibiotics administered in the absence of infection.

Results

We iden

SUBMITTER: Parker R 

PROVIDER: S-EPMC5666044 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature