Integrative analysis of BSG expression in NPC through immunohistochemistry and public high-throughput gene expression data.

ABSTRACT:

Background

Though basigin (BSG) was reported to be overexpressed in nasopharyngeal carcinoma (NPC) and correlate with the development of NPC, the molecular basis of BSG in NPC remained elusive. The aim of the research was to investigate BSG expression in NPC and the potential molecular mechanism underlying it.

Materials and methods

BSG expression in NPC tissues was detected with immunohistochemistry. Chi-square test, Kruskal-Wallis test and Spearman correlation test were performed to examine the relationship between BSG expression and the clinico-pathological features as well as EGFR and P-53 expression in NPC. In addition, data from the Human Protein Atlas (HPA) database and oncomine were collected to validate BSG expression in NPC. Meta-analysis was conducted to investigat

SUBMITTER: Gao L 

PROVIDER: S-EPMC5666066 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature