CD4 T-Cell Dysregulation in Psoriatic Arthritis Reveals a Regulatory Role for IL-22.

ABSTRACT: Dysregulation of interleukin-22 (IL-22) has been associated with autoimmune diseases but divergent effects upon inflammation have hampered efforts to define its contribution to pathogenesis. Here, we examined the role of IL-22 in patients with psoriatic arthritis (PsA). In the peripheral blood of PsA patients, there was a decrease in IL-22⁺CD4⁺ T cells compared with healthy controls resulting in a heightened CD4⁺ IFNγ⁺/IL-22⁺ ratio accompanied by diminished CCR6 expression. IL-22 expressing cells were depleted primarily from the central memory CD4 T-cell subset in PsA patients. Paradoxically IL-22 and particularly interferon-gamma (IFNγ) production were elevated within a CD4⁺ T-cell subset with phenotypic markers characteris

SUBMITTER: Ezeonyeji A 

PROVIDER: S-EPMC5666299 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature