Identification and Analysis of P53-Mediated Competing Endogenous RNA Network in Human Hepatocellular Carcinoma.

ABSTRACT: Recent studies have indicated that long non-coding RNAs (lncRNAs) and mRNA function as competing endogenous RNAs (ceRNAs) that compete to bind to shared microRNA (miRNA) recognition elements (MREs) to perform specific biological functions during tumorigenesis. The tumor suppressor p53 is a master regulator of cancer-related biological processes by acting as a transcription factor to regulate target genes including miRNA and lncRNA. However, the mechanism in human hepatocellular carcinoma and whether p53-mediated RNA targets could form ceRNA network remain unclear. Here, we identified a series of differential expressed miRNAs, lncRNA and mRNA which were potentially regulated by p53 using RNA sequencing in HepG2. Genomic characteristics comparative analysis showed significant differences bet

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5666336 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature