Ontology highlight
ABSTRACT:
SUBMITTER: Parisis N
PROVIDER: S-EPMC5666611 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
The EMBO journal 20171005 21
Nuclear actin regulates transcriptional programmes in a manner dependent on its levels and polymerisation state. This dynamics is determined by the balance of nucleocytoplasmic shuttling, formin- and redox-dependent filament polymerisation. Here, using <i>Xenopus</i> egg extracts and human somatic cells, we show that actin dynamics and formins are essential for DNA replication. In proliferating cells, formin inhibition abolishes nuclear transport and initiation of DNA replication, as well as gen ...[more]