The Innate and Adaptive Immune System as Targets for Biologic Therapies in Inflammatory Bowel Disease.

ABSTRACT: Inflammatory bowel disease (IBD) is an immune-mediated inflammatory condition causing inflammation of gastrointestinal and systemic cells, with an increasing prevalence worldwide. Many factors are known to trigger and maintain inflammation in IBD including the innate and adaptive immune systems, genetics, the gastrointestinal microbiome and several environmental factors. Our knowledge of the involvement of the immune system in the pathophysiology of IBD has advanced rapidly over the last two decades, leading to the development of several immune-targeted treatments with a biological source, known as biologic agents. The initial focus of these agents was directed against the pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) leading to dramatic changes in the disease course for a prop

SUBMITTER: Holleran G 

PROVIDER: S-EPMC5666702 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature