MicroRNA-34a: A Versatile Regulator of Myriads of Targets in Different Cancers.

ABSTRACT: MicroRNA-34a (miR-34a) is a tumor suppressor that has attracted considerable attention in recent years. It modulates cancer cell invasion, metastasis, and drug resistance, and has also been evaluated as a diagnostic and/or prognostic biomarker. A number of targets of miR-34a have been identified, including some other non-coding RNAs, and it is believed that the modulation of these myriads of targets underlines the versatile role of miR-34a in cancer progression and pathogenesis. Seemingly appealing results from preclinical studies have advocated the testing of miR-34a in clinical trials. However, the results obtained are not very encouraging and there is a need to re-interpret how miR-34a behaves in a context dependent manner in different cancers. In this review, we have attempted to summa

SUBMITTER: Farooqi AA 

PROVIDER: S-EPMC5666771 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature