Prebiotics Mediate Microbial Interactions in a Consortium of the Infant Gut Microbiome.

ABSTRACT: Composition of the gut microbiome is influenced by diet. Milk or formula oligosaccharides act as prebiotics, bioactives that promote the growth of beneficial gut microbes. The influence of prebiotics on microbial interactions is not well understood. Here we investigated the transformation of prebiotics by a consortium of four representative species of the infant gut microbiome, and how their interactions changed with dietary substrates. First, we optimized a culture medium resembling certain infant gut parameters. A consortium containing Bifidobacterium longum subsp. infantis, Bacteroides vulgatus, Escherichia coli and Lactobacillus acidophilus was grown on fructooligosaccharides (FOS) or 2'-fucosyllactose (2FL) in mono- or co-culture. While Bi. infant

SUBMITTER: Medina DA 

PROVIDER: S-EPMC5666777 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature