Understanding the Contribution of Zinc Transporters in the Function of the Early Secretory Pathway.

ABSTRACT: More than one-third of newly synthesized proteins are targeted to the early secretory pathway, which is comprised of the endoplasmic reticulum (ER), Golgi apparatus, and other intermediate compartments. The early secretory pathway plays a key role in controlling the folding, assembly, maturation, modification, trafficking, and degradation of such proteins. A considerable proportion of the secretome requires zinc as an essential factor for its structural and catalytic functions, and recent findings reveal that zinc plays a pivotal role in the function of the early secretory pathway. Hence, a disruption of zinc homeostasis and metabolism involving the early secretory pathway will lead to pathway dysregulation, resulting in various defects, including an exacerbation of homeostatic ER stress.

SUBMITTER: Kambe T 

PROVIDER: S-EPMC5666860 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature