G-Protein Dependent Signal Transduction and Ubiquitination in Dictyostelium.

ABSTRACT: Signal transduction through G-protein-coupled receptors (GPCRs) is central for the regulation of virtually all cellular functions, and it has been widely implicated in human diseases. These receptors activate a common molecular switch that is represented by the heterotrimeric G-protein generating a number of second messengers (cAMP, cGMP, DAG, IP3, Ca2+ etc.), leading to a plethora of diverse cellular responses. Spatiotemporal regulation of signals generated by a given GPCR is crucial for proper signalling and is accomplished by a series of biochemical modifications. Over the past few years, it has become evident that many signalling proteins also undergo ubiquitination, a posttranslational modification that typically leads to protein degradation, but also mediates processes such as protei

SUBMITTER: Pergolizzi B 

PROVIDER: S-EPMC5666861 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature