Altered resting state functional connectivity of fear and reward circuitry in comorbid PTSD and major depression.

ABSTRACT:

Background

Individuals with comorbid posttraumatic stress disorder and major depressive disorder (PTSD-MDD) often exhibit greater functional impairment and poorer treatment response than individuals with PTSD alone. Research has not determined whether PTSD-MDD is associated with different network connectivity abnormalities than PTSD alone.

Methods

We used functional magnetic resonance imaging (fMRI) to measure resting state functional connectivity (rs-FC) patterns of brain regions involved in fear and reward processing in three groups: patients with PTSD-alone (n = 27), PTSD-MDD (n = 21), and trauma-exposed healthy controls (TEHCs, n = 34). Based on previous research, seeds included basolateral amygdala (BLA), centromedial amygdala (CMA), and nucleus accumbens (NAcc).

Res

SUBMITTER: Zhu X 

PROVIDER: S-EPMC5667358 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature