Minimal sufficient balance randomization for sequential randomized controlled trial designs: results from the ESCAPE trial.

ABSTRACT:

Background

We describe the implementation of minimal sufficient balance randomization, a covariate-adaptive randomization technique, used for the "Endovascular treatment for Small Core and Anterior circulation Proximal occlusion with Emphasis on minimizing CT to recanalization times" (ESCAPE) trial.

Methods

The ESCAPE trial is a prospective, multicenter, randomized clinical trial that enrolled subjects with the following main inclusion criteria: less than 12 h from symptom onset, age 18 years or older, baseline NIHSS score > 5, ASPECTS score > 5 and computed tomography angiography (CTA) evidence of carotid T/L or M1-segment middle cerebral artery (MCA) occlusion, and at least moderate collaterals by CTA. Patients were randomized using a real-time, dynamic, Internet-based, mi

SUBMITTER: Sajobi TT 

PROVIDER: S-EPMC5667454 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature