Lipid Metabolism, Abdominal Adiposity, and Cerebral Health in the Amish.

ABSTRACT:

Objective

To assess the association between peripheral lipid/fat profiles and cerebral gray matter (GM) and white matter (WM) in healthy Old Order Amish (OOA).

Methods

Blood lipids, abdominal adiposity, liver lipid contents, and cerebral microstructure were assessed in OOA (N = 64, 31 males/33 females, ages 18-77). Orthogonal factors were extracted from lipid and imaging adiposity measures. GM assessment used the Human Connectome Project protocol to measure whole-brain average cortical thickness. Diffusion-weighted imaging was used to derive WM fractional anisotropy and kurtosis anisotropy measurements.

Results

Lipid/fat measures were captured by three orthogonal factors explaining 80% of the variance. Factor one loaded on cholesterol and/or low-density lipoprotein ch

SUBMITTER: Ryan M 

PROVIDER: S-EPMC5667552 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature