Myotome adaptability confers developmental robustness to somitic myogenesis in response to fibre number alteration.

ABSTRACT: Balancing the number of stem cells and their progeny is crucial for tissue development and repair. Here we examine how cell numbers and overall muscle size are tightly regulated during zebrafish somitic muscle development. Muscle stem/precursor cell (MPCs) expressing Pax7 are initially located in the dermomyotome (DM) external cell layer, adopt a highly stereotypical distribution and thereafter a proportion of MPCs migrate into the myotome. Regional variations in the proliferation and terminal differentiation of MPCs contribute to growth of the myotome. To probe the robustness of muscle size control and spatiotemporal regulation of MPCs, we compared the behaviour of wild type (wt) MPCs with those in mutant zebrafish that lack the muscle regulatory factor Myod. Myod^fh261 mutants

SUBMITTER: Roy SD 

PROVIDER: S-EPMC5667637 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature