Beta burst dynamics in Parkinson's disease OFF and ON dopaminergic medication.

ABSTRACT: Exaggerated basal ganglia beta activity (13-35 Hz) is commonly found in patients with Parkinson's disease and can be suppressed by dopaminergic medication, with the degree of suppression being correlated with the improvement in motor symptoms. Importantly, beta activity is not continuously elevated, but fluctuates to give beta bursts. The percentage number of longer beta bursts in a given interval is positively correlated with clinical impairment in Parkinson's disease patients. Here we determine whether the characteristics of beta bursts are dependent on dopaminergic state. Local field potentials were recorded from the subthalamic nucleus of eight Parkinson's disease patients during temporary lead externalization during surgery for deep brain stimulation. The recordings took place with th

SUBMITTER: Tinkhauser G 

PROVIDER: S-EPMC5667742 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature