Effects of uric acid-lowering therapy in patients with chronic kidney disease: A meta-analysis.

ABSTRACT:

Background and objectives

The effects of uric acid-lowering therapy in patients with chronic kidney disease (CKD) remain uncertain. Therefore, we undertook a systematic review and meta-analysis to investigate the effects of uric acid-lowering agents on major clinical outcomes of CKD.

Design, setting, participants, and measurements

According to the pre-specified protocol that was registered with PROSPERO (No. CRD42016038030), we searched systematically in MEDLINE, EMBASE, and the Cochrane Library for trials up to February 2016. Prospective, randomized, controlled trials assessing the effects of uric acid-lowering agents on cardiovascular and kidney outcomes in patients with CKD were included. Random-effects analytical methods were used.

Results

Sixteen eligible trials

SUBMITTER: Su X 

PROVIDER: S-EPMC5667873 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature