Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission.

ABSTRACT:

Background

Proteinuria is a powerful prognostic factor for end-stage renal disease in IgA nephropathy (IgAN) patients. However, it is not known whether proteinuria exacerbations are related to seasonal changes.

Methods

We retrospectively enrolled consecutive patients diagnosed with IgAN by kidney biopsy at our hospital between 2002 and 2014. Proteinuria remission was defined as urinary protein <0.3 g/gCr in two consecutive outpatient urinalyses and exacerbation as urinary protein ≥0.75 g/gCr. Four seasons were defined: spring (March-May), summer (June-August), autumn (September-November), and winter (December-February). We performed a multivariate analysis to identify factors associated with the second remission following a proteinuria exacerbation.

Results

We analyze

SUBMITTER: Inagaki K 

PROVIDER: S-EPMC5667876 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature