Prediction of new brain metastases after radiosurgery: validation and analysis of performance of a multi-institutional nomogram.

ABSTRACT: Stereotactic radiosurgery (SRS) without whole brain radiotherapy (WBRT) for brain metastases can avoid WBRT toxicities, but with risk of subsequent distant brain failure (DBF). Sole use of number of metastases to triage patients may be an unrefined method. Data on 1354 patients treated with SRS monotherapy from 2000 to 2013 for new brain metastases was collected across eight academic centers. The cohort was divided into training and validation datasets and a prognostic model was developed for time to DBF. We then evaluated the discrimination and calibration of the model within the validation dataset, and confirmed its performance with an independent contemporary cohort. Number of metastases (≥8, HR 3.53 p = 0.0001), minimum margin dose (HR 1.07 p = 0.0033), and melanoma histology (HR 1.45,

SUBMITTER: Ayala-Peacock DN 

PROVIDER: S-EPMC5667906 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature