Endostar in combination with postoperative adjuvant chemotherapy prolongs the disease free survival of stage IIIA NSCLC patients with high VEGF expression.

ABSTRACT:

Purpose

The aim of this study is to compare the therapeutic effect between endostar plus adjuvant chemotherapy and adjuvant chemotherapy alone in the patients with completely resected non-small cell lung cancer (NSCLC) at stage IB to IIIA.

Experimental design

This is an open, multicenter, randomized (1:1) study with 250 NSCLC patients. Completely resected NSCLC patients at stages IB to IIIA were randomized to receive adjuvant NP plus endostar (Vinorelbine 25 mg/m² on day 1 and day 8 plus Cisplatin 75 mg/m² on day 1, and plus endostar 7.5 mg/m² per day iv for consecutive 14 days) or NP regimen alone. Every 21 days were set as one cycle for 4 cycles. The primary endpoint was disease-free survival (DFS). Secondary endpoints included tumor respon

SUBMITTER: Chen Z 

PROVIDER: S-EPMC5668083 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature