Impact of lean mass and bone density on glomerular filtration rate estimation in people living with HIV/AIDS.

ABSTRACT:

Context

Chronic kidney disease is a frequent complication in persons living with HIV/AIDS. Although previous studies have suggested that the CKD-EPI formula is appropriate to estimate glomerular filtration rate (GFR) in HIV-positive adults with normal kidney function, the optimal way to estimate GFR in those with Stage 3 chronic kidney disease is not known. Moreover, the impact of muscle mass on creatinine level and GFR estimation is unknown.

Aim and methods

Our study aimed to evaluate the accuracy of different diagnostic tests available compared to the gold standard measurement of GFR. A group of 44 HIV-1 patients with an estimated GFR between 60 and 30 ml/min/1.73 m2 were included in a single-center cross-sectional study. Serum creatinine and cystatin C were measured. GFR

SUBMITTER: Isnard Bagnis C 

PROVIDER: S-EPMC5668131 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature