Treg Depletion Licenses T Cell-Driven HEV Neogenesis and Promotes Tumor Destruction.

ABSTRACT: T-cell infiltration into tumors represents a critical bottleneck for immune-mediated control of cancer. We previously showed that this bottleneck can be overcome by depleting immunosuppressive Foxp3⁺ regulatory T cells (Tregs), a process that can increase frequencies of tumor-infiltrating lymphocytes through promoting the development of specialized portals for lymphocyte entry, namely high endothelial venules (HEVs). In this paper, we used a carcinogen-induced tumor model that allows for coevolution of the tumor microenvironment and the immune response to demonstrate that Treg depletion not only results in widespread disruption to HEV networks in lymph nodes (LNs) but also activates CD8⁺ T cells, which then drive intratumoral HEV development. Formation of these vessel

SUBMITTER: Colbeck EJ 

PROVIDER: S-EPMC5668144 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature