Underreporting of Research Biopsies from Clinical Trials in Oncology.

ABSTRACT: Purpose: Research biopsies are frequently incorporated within clinical trials in oncology and are often a mandatory requirement for trial enrollment. However, limited information is available regarding the extent and completeness of research biopsy reporting.Experimental Design: We identified a cohort of therapeutic clinical trials where research biopsies were performed between January 2005 and October 2010 from an IR database at our institution. Clinical trial protocols were compared with the highest level of corresponding publication as a manuscript or registry report.Results: A total of 866 research biopsies were performed across 46 clinical trials, with a median of 8 patients biopsied/trial and 19 biopsies collected/trial. After a median follow-up time of 4.3 years

SUBMITTER: Parseghian CM 

PROVIDER: S-EPMC5668146 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature