Relationships between Circulating and Intraprostatic Sex Steroid Hormone Concentrations.

ABSTRACT: Background: Sex hormones have been implicated in prostate carcinogenesis, yet epidemiologic studies have not provided substantiating evidence. We tested the hypothesis that circulating concentrations of sex steroid hormones reflect intraprostatic concentrations using serum and adjacent microscopically verified benign prostate tissue from prostate cancer cases.Methods: Incident localized prostate cancer cases scheduled for surgery were invited to participate. Consented participants completed surveys, and provided resected tissues and blood. Histologic assessment of the ends of fresh frozen tissue confirmed adjacent microscopically verified benign pathology. Sex steroid hormones in sera and tissues were extracted, chromatographically separated, and then quantitated by radioimmu

SUBMITTER: Cook MB 

PROVIDER: S-EPMC5668163 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature