Molecular Pathways: Targeting the Microenvironment of Liver Metastases.

ABSTRACT: Curative treatment for metastatic solid cancers remains elusive. The liver, which is nourished by a rich blood supply from both the arterial and portal venous systems, is the most common site of visceral metastases, particularly from cancers arising in the gastrointestinal tract, with colorectal cancer being the predominant primary site in Western countries. A mounting body of evidence suggests that the liver microenvironment (LME) provides autocrine and paracrine signals originating from both parenchymal and nonparenchymal cells that collectively create both pre- and prometastatic niches for the development of hepatic metastases. These resident cells and their molecular mediators represent potential therapeutic targets for the prevention and/or treatment of liver metastases (LM). This rev

SUBMITTER: Milette S 

PROVIDER: S-EPMC5668192 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature