Effects of combination therapy using antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation.

ABSTRACT:

Background

No single anticoagulant has been proven effective for sepsis-associated disseminated intravascular coagulation (DIC). Thus, the concomitant use of antithrombin concentrate and recombinant thrombomodulin has been conceived. This observational study was conducted to investigate the efficacy and safety of this combination therapy.

Methods

A total of 510 septic DIC patients who received antithrombin substitution were retrospectively analyzed. Among them, 228 were treated with antithrombin and recombinant thrombomodulin (combination therapy) and the rest were treated with antithrombin alone (monotherapy). Propensity score matching created 129 matched pairs, and 28-day all-cause mortality, DIC scores, the sequential organ failure assessment (SOFA) scores, and the incide

SUBMITTER: Iba T 

PROVIDER: S-EPMC5668219 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature