Puerarin attenuates diabetic kidney injury through the suppression of NOX4 expression in podocytes.

ABSTRACT: Radix puerariae, a traditional Chinese herbal medication, has been used to treat patients with diabetic nephropathy (DN). Several studies demonstrated that puerarin, the active compound of radix puerariae, reduces diabetic injury in streptozotocin (STZ)-induced diabetic rodent models. However, as STZ injection alone results in mild kidney injury, the therapeutic benefit afforded by puerarin in DN remained inconclusive. Thus we sought to clarify the role of puerarin by employing an accelerated DN model, STZ-induced diabetes in the endothelial nitric oxide synthase-null (eNOS^-/-) mice. Puerarin treatment of diabetic eNOS^-/- mice significantly attenuated albuminuria and diabetic kidney injury, which were associated with reduced oxidative stress and reduced NAPDH oxidase

SUBMITTER: Li X 

PROVIDER: S-EPMC5668268 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature