Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling.

ABSTRACT: Thrombopoietin (TPO) is the master cytokine regulator of megakaryopoiesis. In addition to regulation of megakaryocyte and platelet number, TPO is important for maintaining proper hematopoietic stem cell (HSC) function. It was previously shown that a number of lymphoid genes were upregulated in HSCs from Tpo ^-/- mice. We investigated if absent or enhanced TPO signaling would influence normal B-lymphopoiesis. Absent TPO signaling in Mpl ^-/- mice led to enrichment of a common lymphoid progenitor (CLP) signature in multipotential lineage-negative Sca-1⁺c-Kit⁺ (LSK) cells and an increase in CLP formation. Moreover, Mpl ^-/- mice exhibited increased numbers of PreB2 and immature B-cells in bone marrow and spleen, with an increased proportion

SUBMITTER: Au AE 

PROVIDER: S-EPMC5668349 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature