Ontology highlight
ABSTRACT:
SUBMITTER: Chu AY
PROVIDER: S-EPMC5668367 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature communications 20171103 1
Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham Heart Study participants to identify epigenetic signatures of kidney function. Of 19 CpG sites significantly associated (P < 1e-07) with eGFR/CKD and replicated, five also associat ...[more]