P22phox C242T gene polymorphism and overt diabetic nephropathy: a meta-analysis of 1,452 participants.

ABSTRACT:

Background/aims

The p22phox C242T gene polymorphism (rs4673) may be linked to an increased susceptibility for overt diabetic nephropathy (ODN), but the study results are still inconclusive.

Methods

To explore the relationship between p22phox C242T gene polymorphism and ODN, the current meta-analysis of 707 ODN patients and 745 controls from five individual studies was conducted. The pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) were evaluated by either a random or fixed effect model.

Results

In our meta-analysis, a significant relationship between the p22phox C242T gene polymorphism and ODN was found under allelic (OR, 2.760; 95% CI, 1.400 to 5.450; p = 0.004), recessive (OR, 5.080; 95% CI, 1.020 to 25.430; p = 0.05), dominant (OR, 1.700; 9

SUBMITTER: Li YY 

PROVIDER: S-EPMC5668385 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature