Differential protein-coding gene and long noncoding RNA expression in smoking-related lung squamous cell carcinoma.

ABSTRACT:

Background

Cigarette smoking is one of the greatest preventable risk factors for developing cancer, and most cases of lung squamous cell carcinoma (lung SCC) are associated with smoking. The pathogenesis mechanism of tumor progress is unclear. This study aimed to identify biomarkers in smoking-related lung cancer, including protein-coding gene, long noncoding RNA, and transcription factors.

Methods

We selected and obtained messenger RNA microarray datasets and clinical data from the Gene Expression Omnibus database to identify gene expression altered by cigarette smoking. Integrated bioinformatic analysis was used to clarify biological functions of the identified genes, including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, the construction of

SUBMITTER: Li S 

PROVIDER: S-EPMC5668523 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature