Role of gabra2, GABA_A receptor alpha-2 subunit, in CNS development.

ABSTRACT: gabra2 gene codes for the alpha-2 subunit of the GABA_A receptor, one of the ionotropic receptors which has been related to anxiety, depression and other behavioural disorders, including drug dependence and schizophrenia. GABAergic signalling also plays a role during development, by promoting neural stem cell maintenance and renewal. To investigate the role of gabra2 in CNS development, gabra2 deficient zebrafish were generated. The pattern of proliferation during the embryonic development was disrupted in morphant embryos, which also displayed an increase in the number of apoptotic nuclei mainly at the mid- and hindbrain regions. The expression of several genes (notch1, pax2, fgf8 and wnt1) known to contribute to the development of the central

SUBMITTER: Gonzalez-Nunez V 

PROVIDER: S-EPMC5668850 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature