Merging single-shot XFEL diffraction data from inorganic nanoparticles: a new approach to size and orientation determination.

ABSTRACT: X-ray free-electron lasers (XFELs) provide new opportunities for structure determination of biomolecules, viruses and nanomaterials. With unprecedented peak brilliance and ultra-short pulse duration, XFELs can tolerate higher X-ray doses by exploiting the femtosecond-scale exposure time, and can thus go beyond the resolution limits achieved with conventional X-ray diffraction imaging techniques. Using XFELs, it is possible to collect scattering information from single particles at high resolution, however particle heterogeneity and unknown orientations complicate data merging in three-dimensional space. Using the Linac Coherent Light Source (LCLS), synthetic inorganic nanocrystals with a core-shell architecture were used as a model system for proof-of-principle coherent diffractive single-

SUBMITTER: Li X 

PROVIDER: S-EPMC5668859 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature