Electrospun bioactive mats enriched with Ca-polyphosphate/retinol nanospheres as potential wound dressing.

ABSTRACT:

Background

While electrospun materials have been frequently used in tissue engineering no wound dressings exist that significantly improved wound healing effectively.

Methods

We succeeded to fabricate three-dimensional (3D) electrospun poly(D,l-lactide) (PLA) fiber mats into which nanospheres, formed from amorphous calcium polyphosphate (polyP) nanoparticles (NP) and encapsulated retinol ("retinol/aCa-polyP-NS" nanospheres [NS]), had been incorporated.

Results

Experiments with MC3T3-E1 cells revealed that co-incubation of the cells with Ca-polyP together with retinol (or incubation with retinol/aCa-polyP-NS) resulted in a significant synergistic effect on cell growth compared with particle-free polyP complexed with Ca²⁺ or amorphous Ca-polyP NPs and retinol

SUBMITTER: Muller WEG 

PROVIDER: S-EPMC5668879 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature