Identifying <i>cis</i>-mediators for <i>trans</i>-eQTLs across many human tissues using genomic mediation analysis.

ABSTRACT: The impact of inherited genetic variation on gene expression in humans is well-established. The majority of known expression quantitative trait loci (eQTLs) impact expression of local genes (cis-eQTLs). More research is needed to identify effects of genetic variation on distant genes (trans-eQTLs) and understand their biological mechanisms. One common trans-eQTLs mechanism is "mediation" by a local (cis) transcript. Thus, mediation analysis can be applied to genome-wide SNP and expression data in order to identify transcripts that are "cis-mediators" of trans-eQTLs, including those "cis-hubs" involved in regulation of many trans-genes. Identifying such mediators helps us understand regulatory networks and suggests biological mechanism

SUBMITTER: Yang F 

PROVIDER: S-EPMC5668943 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature