Regulatory and evolutionary signatures of sex-biased genes on both the X chromosome and the autosomes.

ABSTRACT:

Background

Sex is an important but understudied factor in the genetics of human diseases. Analyses using a combination of gene expression data, ENCODE data, and evolutionary data of sex-biased gene expression in human tissues can give insight into the regulatory and evolutionary forces acting on sex-biased genes.

Methods

In this study, we analyzed the differentially expressed genes between males and females. On the X chromosome, we used a novel method and investigated the status of genes that escape X-chromosome inactivation (escape genes), taking into account the clonality of lymphoblastoid cell lines (LCLs). To investigate the regulation of sex-biased differentially expressed genes (sDEG), we conducted pathway and transcription factor enrichment analyses on the sDEGs, as w

SUBMITTER: Shen JJ 

PROVIDER: S-EPMC5668987 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature