Relationships Among Obesity, Type 2 Diabetes, and Plasma Cytokines in African American Women.

ABSTRACT:

Objective

The principal objective of this investigation was to identify novel cytokine associations with BMI and type 2 diabetes (T2D).

Methods

Cytokines were profiled from African American women with obesity who donated plasma to the Komen Tissue Bank. Multiplex bead arrays of analytes were used to quantify 88 cytokines and chemokines in association with clinical diagnoses of metabolic health. Regression models were generated after elimination of outliers.

Results

Among women with obesity, T2D was associated with breast adipocyte hypertrophy and with six plasma analytes, including four chemokines (chemokine [C-C motif] ligand 2, chemokine [C-C motif] ligand 16, chemokine [C-X-C motif] ligand 1, and chemokine [C-X-C motif] ligand 16) and two growth factors (interleuki

SUBMITTER: Denis GV 

PROVIDER: S-EPMC5669048 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature