Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease.

ABSTRACT:

Background

Plasminogen activator inhibitor type 1 (PAI-1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI-1 levels are associated with increased risk of coronary heart disease (CHD). However, it is unclear whether the association reflects a causal influence of PAI-1 on CHD risk.

Methods and results

To evaluate the association between PAI-1 and CHD, we applied a 3-step strategy. First, we investigated the observational association between PAI-1 and CHD incidence using a systematic review based on a literature search for PAI-1 and CHD studies. Second, we explored the causal association between PAI-1 and CHD using a Mendelian randomization approach using summary statistics from large genome-wide association stud

SUBMITTER: Song C 

PROVIDER: S-EPMC5669150 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature