RARα and RARγ reciprocally control K5⁺ progenitor cell expansion in developing salivary glands.

ABSTRACT: Understanding the mechanisms of controlled expansion and differentiation of basal progenitor cell populations during organogenesis is essential for developing targeted regenerative therapies. Since the cytokeratin 5-positive (K5⁺) basal epithelial cell population in the salivary gland is regulated by retinoic acid signaling, we interrogated how isoform-specific retinoic acid receptor (RAR) signaling impacts the K5⁺ cell population during salivary gland organogenesis to identify RAR isoform-specific mechanisms that could be exploited in future regenerative therapies. In this study, we utilized RAR isoform-specific inhibitors and agonists with murine submandibular salivary gland organ explants. We determined that RARα and RARγ have opposing effects on K5⁺ cel

SUBMITTER: DeSantis KA 

PROVIDER: S-EPMC5669212 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature