Aerobic exercise prevents rarefaction of pial collaterals and increased stroke severity that occur with aging.

ABSTRACT: Variation in extent of the brain's collateral circulation is an important determinant of variation in the severity of stroke and efficacy of revascularization therapies. However, the number and diameter of pial collateral "arterioles" decrease with aging in associated with reduced eNOS and increased oxidative stress. We tested whether exercise reduces this aging-induced rarefaction. Twelve-month-old mice were randomized to sedentary or voluntary wheel-running. At 26 months' age, permanent MCA occlusion was followed 72 h later by determination of infarct volume and vascular casting after maximal dilation. The decline in collateral number and diameter and 2.4-fold increase in infarct volume evident in 26-versus 3-month-old sedentary mice were prevented by exercise-training. In contrast, numb

SUBMITTER: Rzechorzek W 

PROVIDER: S-EPMC5669350 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature