Novel curcumin derivatives as potent inhibitors of amyloid β aggregation.

ABSTRACT: Modulation of abnormal amyloid β (Aβ) aggregation is considered to be a potential therapeutic target for Alzheimer's disease (AD). Recent in vitro and in vivo experiments suggest that inhibition of Aβ aggregation by curcumin would exert favorable effects for preventing or treating AD. We have previously synthesized a series of novel curcumin derivatives. In this study, we investigated the effects of our curcumin derivatives on Aβ aggregation and the cell toxicities of Aβ aggregates. According to sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) profiles, 14 of 41 compounds showed a significant increase in the densities of the bands of Aβ (1-42) by incubation during the aggregation process relative to those of Aβ (1-42) prepared in the presence of the vehicl

SUBMITTER: Yanagisawa D 

PROVIDER: S-EPMC5669405 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature