Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles.

ABSTRACT:

Introduction

Autoinflammatory and autoimmune disorders are characterized by aberrant changes in innate and adaptive immunity that may lead from an initial inflammatory state to an organ specific damage. These disorders possess heterogeneity in terms of affected organs and clinical phenotypes. However, despite the differences in etiology and phenotypic variations, they share genetic associations, treatment responses and clinical manifestations. The mechanisms involved in their initiation and development remain poorly understood, however the existence of some clear similarities between autoimmune and autoinflammatory disorders indicates variable degrees of interaction between immune-related mechanisms.

Methods

Our study aims at contributing to a holistic, pathway-centered view

SUBMITTER: Arakelyan A 

PROVIDER: S-EPMC5669448 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature