Heterogeneity and Homogeneity of Regional Brain Structure in Schizophrenia: A Meta-analysis.

ABSTRACT:

Importance

Schizophrenia is associated with alterations in mean regional brain volumes. However, it is not known whether the clinical heterogeneity seen in the disorder is reflected at the neurobiological level, for example, in differences in the interindividual variability of these brain volumes relative to control individuals.

Objective

To investigate whether patients with first-episode schizophrenia exhibit greater variability of regional brain volumes in addition to mean volume differences.

Data sources

Studies that reported regional brain volumetric measures in patients and controls by using magnetic resonance imaging in the MEDLINE, EMBASE, and PsycINFO databases from inception to October 1, 2016, were examined.

Study selection

Case-control studies that r

SUBMITTER: Brugger SP 

PROVIDER: S-EPMC5669456 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature