Inception and deprescribing of statins in people aged over 80 years: cohort study.

ABSTRACT:

Objective

statin use over the age of 80 years is weakly evidence-based. This study aimed to estimate rates of statin inception and deprescribing by frailty level in people aged 80 years or older.

Methods

a cohort of 212,566 participants aged ≥80 years was sampled from the UK Clinical Practice Research Datalink. Statin inception was defined as a first-ever prescription in a non-statin user; deprescribing was defined as a last ever statin prescription more than 6 months before the end of participant records. Rates were estimated in a time-to-event framework allowing for mortality as a competing risk. Co-variates were age, gender, frailty category and prevention type.

Results

prevalent statin use increased from 2001-5 (9.9%) to 2011-15 (49.3%). Inception of statins in ne

SUBMITTER: Gulliford M 

PROVIDER: S-EPMC5669477 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature