Bimodal coupling of ripples and slower oscillations during sleep in patients with focal epilepsy.

ABSTRACT:

Objective

Differentiating pathologic and physiologic high-frequency oscillations (HFOs) is challenging. In patients with focal epilepsy, HFOs occur during the transitional periods between the up and down state of slow waves. The preferred phase angles of this form of phase-event amplitude coupling are bimodally distributed, and the ripples (80-150 Hz) that occur during the up-down transition more often occur in the seizure-onset zone (SOZ). We investigated if bimodal ripple coupling was also evident for faster sleep oscillations, and could identify the SOZ.

Methods

Using an automated ripple detector, we identified ripple events in 40-60 min intracranial electroencephalography (iEEG) recordings from 23 patients with medically refractory mesial temporal lobe or neocortical epi

SUBMITTER: Song I 

PROVIDER: S-EPMC5669821 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature