Negative control of Candida albicans filamentation-associated gene expression by essential protein kinase gene KIN28.

ABSTRACT: The fungus Candida albicans can grow as either yeast or filaments, which include hyphae and pseudohyphae, depending on environmental conditions. Filamentous growth is of particular interest because it is required for biofilm formation and for pathogenesis. Environmentally induced filamentous growth is associated with expression of filamentation-associated genes, and both filamentous growth and associated gene expression depend upon several well-characterized transcription factors. Surprisingly, strains with reduced expression of many essential genes display filamentous growth under non-inducing conditions-those in which the wild type grows as yeast. We found recently that diminished expression of several essential protein kinase genes leads to both filamentous cell morphology and filamenta

SUBMITTER: Woolford CA 

PROVIDER: S-EPMC5669822 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature